Mouse Model of Hyperkinesis Implicates SNAP-25 in Behavioral Regulation
نویسندگان
چکیده
منابع مشابه
Mouse model of hyperkinesis implicates SNAP-25 in behavioral regulation.
Although hyperkinesis is expressed in several neurological disorders, the biological basis of this phenotype is unknown. The mouse mutant coloboma (Cml+) exhibits profound spontaneous locomotor hyperactivity resulting from a deletion mutation. This deletion encompasses several genes including Snap, which encodes SNAP-25, a nerve terminal protein involved in neurotransmitter release. Administrat...
متن کاملSNAP-25, enSNAREd in neurotransmission and regulation of behaviour.
20 (1993) Cell 74, 947-950 Geppert, M., Goda, Y., Hammer, R. I;., Li, C., Rosahl, T. W., Stevens, C. F. and Sudhof, T. C. (1994) Cell 79, 717-727 Schiavo, G., Gmachl, M. J. S., Stenbeck G., Sollner, T. €1. and Rothman, J. E. (1995) Nature (London) 378, 733-736 O’Connor, V., Augustine, G. J. and Betz, H. (1994) Cell 76, 785-787 Zhang, J. Z., Davletov, B. A., Sudhof, T. C. and Anderson, R. G. W. ...
متن کاملRegulation of SNAP-25 trafficking and function by palmitoylation.
The SNARE (soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor) protein SNAP-25 (25 kDa synaptosome-associated protein) is essential for regulated exocytosis in neuronal and neuroendocrine cells. Whereas the majority of SNARE proteins contain transmembrane domains, SNAP-25 is instead anchored to membranes by the palmitoylation of a central cysteine-rich region. In this...
متن کاملکلونینگ، بیان و تخلیص پروتئین SNAP-25
Background & Objectives:Clostridial neurotoxin inhibits neurotransmitter release by selective and specific intracellular proteolysis of synaptosomal associated protein of 25KDa (SNAP-25), synaptobrevin/VAMP-2 and syntaxin. SNAP-25 is one of the components that forms docking complex in synaptic ends. This protein is subtrate for botulinum neurotoxins types A,C, and E. Each of these toxin serotyp...
متن کاملDifferential expression of SNAP-25 family proteins in the mouse brain.
Soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP)-25 is a neuronal SNARE protein essential for neurotransmitter release from presynaptic terminals. Three palmitoylated SNAP-25 family proteins: SNAP-25a, SNAP-25b, and SNAP-23, are expressed in the brain, but little is known about their distributions and functions. In the present study, we generated specific antibodies to distin...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1996
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.16-09-03104.1996